Vaccination of cats with Sad23L-nCoV-S vaccine candidate against major variants of SARS-CoV-2

Vaccination of cats with Sad23L-nCoV-S vaccine candidate against major variants of SARS-CoV-2

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Cats are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and risk transmitting viruses to naive cats or humans.Here, based on our novel adenovirus-vectored COVID-19 vaccine, the immunogenicity of Sad23L-nCoV-S vaccine was evaluated in cats by prime-boost vaccinations.Five cats were primed with Audio Video Lead a dose of 108 plaque-forming units (PFUs) Sad23L-nCoV-S vaccine and then boosted with an equal dose of same vaccine at a 4-week interval.Cat serum neutralizing antibody (NAb) titers (the sample dilution at which 50% inhibitory concentration [IC50]) were measured as IC50 15,849 to wild-type strain, IC50 6,591 to Alpha, IC50 2,315 to Beta, IC50 2,744 to Gamma, IC50 1,848 to Delta, and IC50 318 to Omicron variants of pseudotyped SARS-CoV-2 viruses at week 6 post-prime vaccination.All NAb levels to these five variants were ≥IC50 49 from vaccinated cats at week 10, while 48.

8% to Delta and 100% to Omicron variants were Dog Suppliers two injections of the inactivated SARS-CoV-2 vaccines.Robust T cell response of interferon (IFN)-γ to S peptides were detected in vaccinated cats.It was concluded that Sad23L-nCoV-S vaccine could be a promising vaccine candidate against SARS-CoV-2 infection in cats by prime or plus boost vaccinations.